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Students Research
The Biginelli Solid-Phase Synthesis of Dihydropyrimidinones Maria Sacta and Dr. Kenneth Yamaguchi Pyrimidinones and related heterocyclic compounds are an important class of pharmacologically active compounds with a wide range of therapeutic properties (antibacterial, anti-inflammatory, and antiviral). A series of dihydropyrimidinones were synthesized using microwave energy by a three-component Biginelli condensation reaction of an aldehyde, b-keto ester, and urea. The products were then characterized. Microwave-Assisted Solid-Phase Synthesis of Phthalimides Aldo Rancier and Dr. Kenneth Yamaguchi Organic reactions on solid supports have become a useful method to synthesis a variety of target compounds. A series of substituted phthalimides were obtained via a microwave-assisted cyclization cleavage reaction. Amide coupling of a series of amines to a variety of resin-attached substituted phthalic acids resulted in the desired products. Then, product characterization was performed. Synthesis of 3-Substituted Coumarins by the Knoevenagel Condensation Reaction Mariam Israiel and Dr. Kenneth Yamaguchi The preparation of heterocyclic compounds under solvent-free conditions offers several key advantages and represents an important class of compounds with elevated biological activity and industrial importance. The microwave-assisted synthesis of a series of 3-Substituted Coumarins via the condensation of a series of 2-hydroxyaldehydes and dimethylmalonate on silica gel was explored. Analysis of Soil and Water Sample In and Around Sites in Hudson County Kavit Patel and Kenneth Yamaguchi An extensive study of environmental contaminants was initiated at selected locations in Hudson County, New Jersey and other environmentally sensitive sites. Concentration levels of heavy metal contaminants such as lead and chromium and other cations and anions were investigated in soil, river, and lake water samples. Contaminant levels in these samples were assessed by atomic absorption and ion chromatography.
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